iButamoren 750mg (MK-677/Nutrobal)


iButamoren by Nucleus Research

750mg total

25mg per 1ml

30ml bottle

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iButamoren (Mk-677/Nutrobal) is supplied in 30ml of solution giving 25mg per 1ml of solution.

iButamoren is an orally administrated growth hormone secretagogue originally developed by Reverse Pharmacology.

A secretagogue is a term for a substance that causes another substance to be secreted. iButamoren could be compared to peptides like GHRP-6 as it is a ghrelin agonist and binds to the ghrelin receptor causing hunger and GH release.

This GHS (Growth Hormone Secretagogue) was developed with an aim to combat such conditions as muscle wasting, obesity and osteoporosis. It was also targeted towards the treatment of elderly hip fracture patients, so there are a myriad of studies done on safety.

Growth hormone pulse intensity can be increased through 4 possible mechanism:

1. Increasing GHRH (Growth hormone releasing hormone) release.
2. Amplifying GHRH signalling in somatotrophs of the anterior pituitary gland.
3. Reducing somatostatin release (Somatostatin turns off GH release).
4. Inhibiting of somatostatin receptor signalling.

iButamoren was found to work through all four of these mechanisms. After ingestion, Growth Hormone (GH) was shown to increase dose dependently, at doses starting at 10mg a day.


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