Natural MGF is made locally and does not travel into the bloodstream. Synthetic MGF is water based and when administered intramuscularly, travels into the bloodstream.
MGF is only stable in the blood stream for only a few minutes.
Pegylation is the act of attaching a polyethylene glycol (PEG) structure to another larger molecule (in this case, MGF).
The PEG acts as a protective coating and the theory here is that this will allow the MGF to be carried through the blood stream without being broken down.
Neurological research has shown that utilising PEGylated MGF resulted in a longer more stable acting version of the MGF peptide in serum/blood.
MGF is a splice variant of the IGF gene which increases stem cell count in the muscle and allows for muscle fibres to fuse and mature in the animal test subject.